Anthocyanins from Black Chokeberry Delayed Ageing-related Degenerative Changes in the Heart
By: Xu, Dexin
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Contributor(s): Yang, Jing.
Publisher: Bengaluru Indian journal of pharmaceutical education and research 2019Edition: Vol.53(1), Jan-Mar.Description: 112-116p.Subject(s): PHARMACEUTICSOnline resources: Click here
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Indian journal of pharmaceutical education and researchSummary: Aim: Aging is the greatest risk factor for most neurodegenerative diseases. Cardiovascular circulatory system is an important part of maintaining normal human life activities. The core of the aging process is DNA damage, a food additive called Anthocyanin which has shown high efficacy in preventing aging, We examine whether anthocyanins could keep young mice from accelerated ageing of the heart. Materials and Methods: In order to accelerate ageing, MiceofKunming were injected with D-galactose and they were given anthocyanins of 20 and 40 mg/kg as an intervention. Results: The whole function and structure of heart were evaluated after eight weeks and the expression levels of genes involved in the DNA damage signalling pathway were evaluated through Western blot analysis.Reduction of the heart index and the heart tissue damage was delayed by Anthocyanins. it maintained the stability of the redox system in serum such as GSH-PX, T-SOD and MDA and heart tissue. In the DNA damage signalling pathway, the expression levels of sensors such as ATM and ATR and effectors such as Chk1 and Chk2 were reduced. Conclusion: Anthocyanins can be diffusely used to slow ageing-related deterioration of heart structure and function by inhibiting DNA damage in the field of health products
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School of Pharmacy Archieval Section | Not for loan | 2019962 |
Aim: Aging is the greatest risk factor for most neurodegenerative diseases. Cardiovascular circulatory system is an important part of maintaining normal human life activities. The core of the aging process is DNA damage, a food additive called Anthocyanin which has shown high efficacy in preventing aging, We examine whether anthocyanins could keep young mice from accelerated ageing of the heart. Materials and Methods: In order to accelerate ageing, MiceofKunming were injected with D-galactose and they were given anthocyanins of 20 and 40 mg/kg as an intervention. Results: The whole function and structure of heart were evaluated after eight weeks and the expression levels of genes involved in the DNA damage signalling pathway were evaluated through Western blot analysis.Reduction of the heart index and the heart tissue damage was delayed by Anthocyanins. it maintained the stability of the redox system in serum such as GSH-PX, T-SOD and MDA and heart tissue. In the DNA damage signalling pathway, the expression levels of sensors such as ATM and ATR and effectors such as Chk1 and Chk2 were reduced. Conclusion: Anthocyanins can be diffusely used to slow ageing-related deterioration of heart structure and function by inhibiting DNA damage in the field of health products
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